Grounded in Research

Natural Natural looks to the plant for cannabinoids and to science to prove their efficacy. Natural Natural THCV is made from phytocannabinoids created by an enzyme inside the plant, and is backed by scientific research. Learn more about our GSD Efficacy Study and Joyride Blind Experience Trial.

GSD Efficacy Study

Natural Natural set out to prove that THCV works in the body the way we think it does: by improving energy, motivation and mood. To do this we completed a research study on the effects of Get Sh!t Done (GSD) THCV.* 

To examine the effects of GSD on energy level, well-being, motivation, and appetite, we gave study participants unlabeled packages of unmedicated placebo gummies, THC-only gummies, and gummies made with Get Sh!t Done™ (GSD) THCV. The GSD gummies included distillate from the GSD plant with a roughly 2:1 ratio of THCV:THC.

The results showed what we’d hoped: those who tried the GSD gummy were more energized and  joyful, and they did not experience the munchies or fatigue from THC.

GSD Study Methods

78 Participants

This first-of-its-kind, IRB approved, double-blind clinical trial included 78 participants.

3 Samples

Each participant was given 3 unlabeled samples:

  1. Placebo (unmedicated)

  2. THC (5mg)

  3. GSD (6.5mg THCV : 3.4mg THC)

Frequency

Participants ingested each gummy type 3x and reported daily on their energy, activity, motivation, focus, appetite, and adverse events.

GSD Study Results

GSD increased activity, exercise performance, motivation, and well-being compared to the placebo, without the fatigue and munchies associated with THC consumption.

We announced the results of the study and our launch of Natural Natural in a recent press release. Read the Press Release on phylos.bio.

*The results of this study may not apply to efficacy of synthetic THCV due to frequent presence of off target molecules created during chemical conversion.

Chart with neon green bars showing placebo at approximately 25-30%, GSD at approximately 30-35%, and THC at approximately 40-45% reporting increased appetite

No Increased Appetite

For the THC-only gummy, participants reported increased hunger when taking full doses. The GSD gummy ameliorated the munchies associated with THC consumption, with no statistical difference in reports of hunger between placebo and GSD gummies.

Chart displays percent reporting increased appetite.

Chart with neon green bars showing placebo at approximately 13, GSD at approximately 5, and THC at approximately 18 reports of fatigue

Less Fatigue

Participants who consumed the GSD gummy reported significantly less fatigue than placebo and THC-only gummies. Participants who consumed the THC-only gummy reported feeling fatigue three times more than the GSD group.

Chart displays reports of fatigue.

Chart with neon green bars showing placebo at approximately 50-60% and GSD at approximately 70-80% reporting increased joy

More Joy

40% more participants reported enjoying their daily activities after consuming a GSD gummy versus placebo.

Chart displays percent reporting increased joy.

Chart with neon green bars showing placebo at approximately 65-70% and GSD at approximately 80-90% reporting increased energy

More Energy

20% more participants felt energized after consuming the GSD gummy over placebo.

Chart displays percent reporting increased energy.

Joyride Blind Experience Trial

Natural Natural explored the effects of THCV in a blind partner experience trial. To examine the effects of Joyride on appetite, exercise motivation, energy, and cognitive impairment, we surveyed participants who smoked prerolls containing ~20% total cannabinoids with either THC only or 1:1 THCV:THC (Joyride).

Joyride Study Methods

30 Participants

Blind experience trial surveyed 30 participants.

3 Samples

Each participant was given 2 unlabeled samples with ~20% total cannabinoids:

  1. THC only

  2. 1 : 1 THCV : THC (Joyride)

Frequency

Participants smoked prerolls and reported on their energy, activity, motivation, focus, appetite, and adverse events.

Joyride Study Results

Joyride increased energy and the ability to exercise without feeling tired; and reported reduced munchies compared to the THCV-only preroll.

  • illustration of burger and soda

    Reduced munchies

    Participants exhibited a strong trend for increased appetite after smoking the THC preroll comparatively indicating munchie behavior associated with THC is mitigated in the THCV preroll.

  • illustration of person biking

    Exercise without feeling tired

    Regular cannabis consumers indicated an increased ability to exercise without feeling tired after smoking the THCV preroll, comparatively to the THC preroll.

    * Participants that regularly smoke THC 2+ times per week.

  • illustration of lightning bolt

    Energized and more active

    When participants smoked the THCV preroll and reported on their exercise level, there was a significant positive effect on feeling energized.

    * Participants that exercise four or more times per week.

  • illustration of a couch

    Uncoordinated, low motivation for physical activity

    Participants felt uncoordinated when smoking the THC only preroll, but did not have this effect with the THCV preroll.

  • illustration of a happy brain

    Less cognitive impairment

    When compared to the THC preroll, participants reported less congnitive impairment after smoking the THCV preroll.